Beyond Erythromycin ...

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Preparation and evaluation of a new erythromycin derivative -- erythromycin taurate.

Erythromycin taurate, a new derivative of erythromycin, was prepared by reacting erythromycin base with tauric acid and its physico-chemical and biological properties were evaluated. The derivative has reasonably good solubility in organic solvents. The partition coefficient values in chloroform/water 1.17 and octanol/water 1.16 systems indicate its good distribution in various tissues in vivo....

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Erythromycin inhibits Cl secretion

We read with interest the report of erythromycin reducing chloride secretion in canine tracheal epithelium (1]. However, we would like to caution against extrapolating from dog to man. Canine trachea is virtually unique in its ion transport properties predominantly secreting chloride, a process which is stimulated by endogenous prostaglandin synthesis. The shortcircuit current of human airways ...

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Erythromycin in trachoma.

Material and Methods A series of 100 patients with trachoma in the infiltrative or follicular stage, in which inclusion bodies could be seen, was selected for this study. Conjunctival scrapings were obtained from the upper fornix by a sharp curette and spread on a slide, care being taken that no blood oozed out. The scrapings were stained by methylene blue and citric acid stain according to the...

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Assay of erythromycin esters.

To the Editor: It was disturbing to read the article entitled “Studies of the Stability of 18 Chemical Constituents,” in the December, 1972, issue of Clinical Chemistry (1). The authors define their conditions of collection and storage but do not, however, make it clear what their object is. If the objective was to show stability of serum before analysis, then their data are misleading. For exa...

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Erythromycin in early syphilis.

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ژورنال

عنوان ژورنال: Canadian Journal of Infectious Diseases

سال: 1994

ISSN: 1180-2332

DOI: 10.1155/1994/450276